Hot Topics in Medicinal Chemistry (Track)

Dental Alveolar Osteoporosis Causing Periodontal Disease Heralds Systemic Osteoporosis, Both Serious World - Wide Health Problems

Y. Takaishi
Takaishi Dental Clinic, Osaka Dental University, Katsuragi Hospital, Osaka, Japan

Abstract:

The usefulness of a new method for the measurement of dental alveolar bone density in osteoporosis screening was evaluated.

In 35 postmenopausal females with a mean age of 59.7 years ( 50 - 69), alveolar bone mineral density (alBMD) was measured by Bone Right System (Dentalgraphic・Com, Himeji, Japan) at a site 6 mm lower than neck of the right mandibular first premolar along with lumbar BMD (LBMD) measurement by DXA(Hologic 4500W, USA) and survey on history of fracture.

Volumetric alveolar BMD was measured by correcting conventional BMD with the right mandibular first premolar, alveolar thickness (T), (ValBMD). Total alveolar BMD was calculated by multiphying alBMD by T (TalBMD).

A significant negative correlation was found between age and al BMD (r= - 0.417, p<0.05).

A significant positive correlation was noted between alBMD and LBMD (r= 0.703, p<0.01).

Fracture increased with age exhibiting a significant positive correlation (r=0.383, p<0.05).

Negative correlation was noted between fracture and LBMD (r= - 0.485, p<0.01), alBMD (r= - 0.631, p<0.01), TalBMD (r= - 0.669, p<0.01, and ValBMD (r= - 0.484, p<0.01). In ROC curves, alBMD, TalBMD and ValBMD. AUC (0.940, 0.917 and 0.857) better than those by LBMD (0.801).